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Metabolic stress, calcium dysregulation and neuroinflammation mediated by glial cells like astrocytes and microglia further exacerbates RGC loss ( In many eye diseases, oxidative stress and mitochondrial dysfunction are key contributors to RGC degeneration

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Obese individuals often exhibit both elevated NNMT in adipose tissue and impaired muscle regenerative capacity a connection that NNMTs dual tissue effects could help explain

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