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These effects are diminished or lost in 3-KO mice, indicating that 3-AR signaling is essential for many, but not all, of AOD9604s actions

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Optic nerve damage: Particularly in individuals with Leber's disease, a hereditary condition that causes retinal degeneration and blindness in children

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The controlled read is a randomised double-blind placebo-controlled Phase 2 enema trial in ulcerative colitis (53 randomised, published only as a meeting abstract) whose confidence interval spans zero and is wider than the point estimate too small to detect the difference it observed, rather than a null result