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High blood pressure is the second most common qualifier

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Studies suggest appetite reduction may begin within a few weeks of starting GLP-1 medications, while meaningful changes in weight metrics may appear after 820 weeks, with continued improvement over 6 months or more

Yet, the etiology appears to be multifactorial, as a number of other causative factors have been suggested for KBD, including fungal toxins in grain, iodine deficiency, and contaminated drinking water (52)

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It does this through independent mechanisms that happen to overlap with what the medication is already doing, which is why the combination often feels disproportionate rather than simply additive