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Taking it on an empty stomach may enhance absorption for some people, though others may need to take it with food to avoid digestive discomfort

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Cholinergic neurons of the enteric nervous system, which interact closely with gastrointestinal epithelial cells, as well as ACh signaling in non-neuronal cells such as enteric glia and pancreatic cells, depend on the essential role of thiamine in ACh production and the facilitation of ACh signaling

doi: 10.1073/pnas.0710402105 49 DalleSRavierMABertrandG

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