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You start low and increase slowly to give your body time to adjust

Patients should maintain a symptom diary documenting the timing, severity, and duration of side effects, along with dietary intake and other relevant factors

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Although the researchers replicate a clinical trial finding of a reduction in heart attacks and strokes among patients with existing cardiovascular disease and chronic kidney disease and a reduction in moderate alcohol consumption risk, they find no statistically significant decline in broader emergency department visits or in any major diagnostic category