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Nrf2 is well known for mediating the expression of antioxidant and detoxifying proteins in response to oxidative and electrophilic stress (reviewed in [162, 163])

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Retatrutide is a triple receptor agonist developed by Eli Lilly, simultaneously targeting GLP-1R, GIPR, and GCGR a combination not seen in any currently approved medicine

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These individuals may experience various complications, such as cardiovascular disease (including type 2 diabetes, hypertension, and hyperlipidemia), metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic syndrome (MS), and endometrial cancer (EC) (Rena and Lang, 2018)

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