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Chronic systemic inflammation, partly triggered and sustained by cytokines, as well as increased oxidative stress contributes to the pathogenesis of this complex metabolic disorder

At present: Think of it as once weekly similar to semaglutide/tirzepatide Future possibility: May move toward once monthly, but not yet established The mechanism of GIP antagonism of cafraglutide is different from GIP agonism of tirzepatide though both the drugs are providing promising positive outcome, why this paradox

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Instead, NICE used different qualitative data collected in the real-word population (i.e., focus group) to illustrate the diseases hidden costs, which resulted in a positive reimbursement decision

B., Cowman, A