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In CRC, the reactivation or remodeling of mitochondrial metabolic pathways, particularly oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO), is closely associated with key oncogenic processes such as the evasion of apoptosis, the maintenance of cancer stem cell properties, and the regulation of redox homeostasis [5,6,7,8]

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Biochimica et biophysica acta (BBA)-general subjects 582(1):6778 Mller SG, Heck SO, Marques LS, Zborowski VA, Nogueira CW (2022) p-Chloro-diphenyl diselenide modulates Nrf2/Keap1 signaling and counteracts renal oxidative stress in mice exposed to repeated dexamethasone administrations

The IGF-2R gene is also subject to parental imprinting with the maternal allele being expressed