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Pharmacological attempts to treat obesity have had limited success, with notable adverse effects, rendering bariatric surgery as the only current therapy for substantially improving body weight

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Material and methods Study design and population We applied a new-user, active comparator cohort study design, comparing GLP-1 RA users with SGLT-2 inhibitor users and GLP-1 RA users with DPP-4 inhibitor users on the incidence of suicide or suicide attempts [19], utilizing information from registers on the entire Danish population [20]