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The latter occurs through dietary protein denaturation in the stomach and subsequent hydrolysis to free riboflavin by alkaline phosphatases and FMN/FAD pyrophosphatases in the ileal brush border to be absorbed in the small intestine [6] [Figure 1]

Seitkazina A, Yang JK, Kim S

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Strong involvement of thiamine transporters in the differentiation of enterocytes is suggested by approximately 6-fold higher thiamine uptake, corresponding to elevated expression of SLC19A2 and SLC19A3, in the differentiated jejunum epithelial cells of the villi, compared to the non-differentiated jejunum epithelial cells of the crypt (152)

One of the main pathomechanisms of AD is oxidative stress, which is closely related to other neurodegenerative events such as impaired calcium homeostasis, metal dysregulation, mitochondrial dysfunction, protein misfolding, inflammation, and impaired autophagy (Nunomura and Perry 2020)

This confirms the peptide is active and enhancing glucose uptake in tissues