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Description

This improvement is associated with decreased melatonin nuclear receptor expression and enhanced cytokine production in lymphocytic and monocytic cell lines, indicating its anti-inflammatory effects [64]

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The chemotherapy-treated group was associated with decreased antioxidant capacity of GSH and CAT levels, and increased the lipid peroxidation marker, MDA, in the hippocampus and prefrontal cortex

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While these findings dont directly translate to humans, they raise legitimate concerns about reproductive health, endocrine disruption, and metabolic stress with prolonged, high-dose usage

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The therapeutic index based upon animal studies is small

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Moreover, Cd toxicity, combined with Fe deficiency, affects electron transportation and causes a reduction in CO 2 fixation and the efficiency of PS II and Chl synthesis (Le kov et al., 2017)

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