SLP-76(Phospho Tyr128) Polyclonal Antibody, 50ul Cell Transfection The encoded protein is thought

The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events

This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules

It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin

The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg)| a macromolecular precursor in thyroid hormone synthesis| while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg

Multiple pseudogenes of this gene have been identified

SLP-76(Phospho Tyr128) Polyclonal Antibody, 50ul Cell Transfection The encoded protein is thoughtSLP 76 was originally identified as a substrate of the ZAP 70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP 76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2 terminus contains an acidic