Shc(Phospho Ser36) Polyclonal Antibody, 50ul Cell Proliferation Component of the PP4 complexes

Component of the PP4 complexes PPP4C-PPP4R1

Its activity is inhibited by spermine| sphingosine| and several phospholipids

Multiple alternatively spliced transcript variants encoding different isoforms have been noted for FGFR2

Gene Ontology (GO) annotations related to this gene include phosphoprotein binding

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Shc(Phospho Ser36) Polyclonal Antibody, 50ul Cell Proliferation Component of the PP4 complexesThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.