IKK alpha/beta(Phospho Ser176/177) Polyclonal Antibody, 100ul Endonucleases & Exonucleases and the nuclear-encoded subunits may

and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex

Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis

Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation

increased chromosomal breakage

Alternative splicing has been observed for this locus and two variants are described

IKK alpha/beta(Phospho Ser176/177) Polyclonal Antibody, 100ul Endonucleases & Exonucleases and the nuclear-encoded subunits mayThis gene encodes a member of the serine threonine protein kinase family. The encoded protein a component of a cytokine activated protein complex that is an inhibitor of the essential transcription factor NF kappa B complex phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway thereby activating the transcription factor.