TSP3 Polyclonal Antibody, 20ul Enzymes & Activity Assays Several alternatively spliced variants of

Several alternatively spliced variants of NCALD have been determined

Mutations in this gene are associated with platelet-type bleeding disorders| which are characterized by a failure of platelet aggregation| including Glanzmann thrombasthenia

and host defense

In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM

and germinal center formation

TSP3 Polyclonal Antibody, 20ul Enzymes & Activity Assays Several alternatively spliced variants ofThe protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell to cell and cell to matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non coding transcript variants.