Rb(Phospho Thr821) Polyclonal Antibody, 100ul Adenovirus Packaging Isoforms are also integral to

Isoforms are also integral to development

Associates with the 9-1-1 complex

Binds preferentially single-stranded DNA and unwinds double stranded DNA

The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates

RIOK1 (RIO kinase 1) includes two alternatively spliced transcript variants

Rb(Phospho Thr821) Polyclonal Antibody, 100ul Adenovirus Packaging Isoforms are also integral toThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.