MDM2(Phospho Ser186/S188) Polyclonal Antibody, 100ul Mammalian Expression This gene encodes a member

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors

Several alternatively spliced transcript variants have been described for this gene

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This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage

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MDM2(Phospho Ser186/S188) Polyclonal Antibody, 100ul Mammalian Expression This gene encodes a memberThis gene encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript