Vimentin Polyclonal Antibody, 100ul[BT-AP09529] Cell Culture Flasks Various mutations of PMP22 are

Various mutations of PMP22 are causes of Charcot-Marie-Tooth disease Type IA

and appears to determine the specificity of the protein's homophilic cell adhesion activity

The encoded protein (B-cell receptor-associated protein 31) is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis

Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation

Mutations in this gene are associated with Warburg micro syndrome type 3

Vimentin Polyclonal Antibody, 100ul[BT-AP09529] Cell Culture Flasks Various mutations of PMP22 areVIM encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. Vimentin encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low density lipoprotein (LDL) derived cholesterol from a lysosome to the