FILA2 Rabbit Polyclonal Antibody, 100ul Molecular Sciences CTSC encodes a member of

CTSC encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system

Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins

Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and PDZ domain binding

Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases

and neurons

FILA2 Rabbit Polyclonal Antibody, 100ul Molecular Sciences CTSC encodes a member ofThe filaggrin like protein encoded by this gene is upregulated by calcium proteolyzed by calpain 1 and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact in addition to providing a physical barrier C terminal fragments of this protein display antimicrobial activity