SIR4 Polyclonal Antibody, 20ul sgRNA Oligos Contains 1 CTCK (C-terminal cystine

Contains 1 CTCK (C-terminal cystine knot-like) domain

Alternatively spliced transcript variants encoding different isoforms have been described for CNTROB

resulting in members with and without DNA-binding properties

2003 [PubMed 12881038])

Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14)

SIR4 Polyclonal Antibody, 20ul sgRNA Oligos Contains 1 CTCK (C-terminal cystineThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular