SSRP1 Rabbit Polyclonal Antibody, 20ul Organelle Studies DNA reparation and mRNA packaging

DNA reparation and mRNA packaging

The protein encoded by this gene is part of the Mediator complex| which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes

It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes

This subunit binds to core promoter sequences encompassing the transcription start site

The encoded protein has been shown to interact with NM23-2

SSRP1 Rabbit Polyclonal Antibody, 20ul Organelle Studies DNA reparation and mRNA packagingThe protein encoded by this gene is a subunit of a heterodimer that along with SUPT16H forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition