MATR3 Polyclonal Antibody, 50ul Antibody Humanization Multiple alternatively spliced transcript variants

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene

Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs

A pseudogene has been identified on the other arm of chromosome 11

The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins

MATR3 Polyclonal Antibody, 50ul Antibody Humanization Multiple alternatively spliced transcript variantsThis gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read through transcripts composed of the upstream small nucleolar RNA host gene 4 (non protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene