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Phospho-ATRIP (S224) Polyclonal Antibody, 20ul Measuring Instruments It is expressed in several

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Phospho-ATRIP (S224) Polyclonal Antibody, 20ul Measuring Instruments It is expressed in severalATRIP (ATR interacting protein) encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for ATRIP.

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Description

It is expressed in several fetal tissues but differently from gamma 1

They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens

Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype

Mutations in KRT18 have been linked to cryptogenic cirrhosis

and F(0) - containing the membrane proton channel

Phospho-ATRIP (S224) Polyclonal Antibody, 20ul Measuring Instruments It is expressed in severalATRIP (ATR interacting protein) encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for ATRIP.

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