GPRC5B Polyclonal Antibody, 20ul Antibodies Beta subunit gene mutations lead

Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II)

which is included in the cadherin superfamily

and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin

It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1

A similar duplicated gene is located next to this gene on chromosome 16

GPRC5B Polyclonal Antibody, 20ul Antibodies Beta subunit gene mutations leadGPRC5B (G protein coupled receptor class C group 5 member B) encodes a member of the type 3 G protein coupled receptor family. Members of this superfamily are characterized by a signature 7 transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants.