Shc(Phospho Tyr427) Polyclonal Antibody, 20ul Biomatrix The protein functions as a

The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions

Among its related pathways are Golgi-to-ER retrograde transport and Factors involved in megakaryocyte development and platelet production

The protein encoded by CLEC6A (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domain fold

which are small GTPases involved in protein transport

It is an adaptor protein localized in the nucleus

Shc(Phospho Tyr427) Polyclonal Antibody, 20ul Biomatrix The protein functions as aThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.