BRCA1 Polyclonal Antibody, 100ul[BT-AP00965] Sealing Film HATs play important roles in

HATs play important roles in regulating chromatin remodeling

Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP)

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Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3

This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein

BRCA1 Polyclonal Antibody, 100ul[BT-AP00965] Sealing Film HATs play important roles inBRCA1encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein (BRCA1, DNA repair associated)combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi subunit protein complex known as the BRCA1 associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C terminal