GCKR Polyclonal Antibody, 100ul Low retention tips which is activated downstream of

which is activated downstream of the Notch pathway

Alternative splicing results in multiple transcripts variants

GO annotations related to this gene include actin binding and kinesin binding

and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level

Overexpression of this gene in mammalian cells conferred a transformed phenotype

GCKR Polyclonal Antibody, 100ul Low retention tips which is activated downstream ofGCKR encodes glucokinase regulator belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non covalently to form an inactive complex with the enzyme. GCKR is considered a susceptibility gene candidate for a form of maturity onset diabetes of the young (MODY).