p53(Phospho Ser6) Polyclonal Antibody, 20ul Apoptosis & Autophagy This protein binds to chromatin

This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage

The protein has 7 transmembrane regions and is located on the cell surface

The encoded protein contains an N-terminal actin-binding domain

which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin)

Knockout studies in mice suggest that the different receptors

p53(Phospho Ser6) Polyclonal Antibody, 20ul Apoptosis & Autophagy This protein binds to chromatinThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.