TNR8 Polyclonal Antibody, 20ul Cell Culture Flasks Four alternatively spliced transcript variants

Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported

This gene encodes a 39S subunit protein

and functions in the p53-dependent DNA damage checkpoint

This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia

It is one of seven related genes or pseudogenes found in a cluster| thought to result from gene duplication| on chromosome 22

TNR8 Polyclonal Antibody, 20ul Cell Culture Flasks Four alternatively spliced transcript variantsThe protein encoded by this gene is a member of the TNF receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body