CtBP1/2(Phospho Ser158/164) Rabbit Polyclonal Antibody, 50ul Aspirating Pipets It functions as a negative

It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand

and like their yeast counterparts

Alternatively spliced transcript variants encoding the same protein have been described

It is initially synthesized as a polyprotein precursor

On the other hand

CtBP1/2(Phospho Ser158/164) Rabbit Polyclonal Antibody, 50ul Aspirating Pipets It functions as a negativecofactor: NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. PTM: ADP ribosylated; when cells are exposed to brefeldin A (BFA). PTM: Sumoylation on Lys 428 is promoted by the E3 SUMO protein