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LKB1 Polyclonal Antibody, 100ul[BT-AP05039] Molecular Sciences |PTM:Constitutively sumoylated by SUMO1| SUMO2

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LKB1 Polyclonal Antibody, 100ul[BT-AP05039] Molecular Sciences |PTM:Constitutively sumoylated by SUMO1| SUMO2STK11 (serine threonine kinase 11), which encodes a member of the serine threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of STK11 have been

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Description

|PTM:Constitutively sumoylated by SUMO1| SUMO2 and SUMO3

but appear to have divergent biological functions

GO annotations related to this gene include poly(A) RNA binding and tRNA binding

while transcript variants initiating downstream of the interspersed NNAT gene (GeneID: 4826) are expressed from the paternal allele

and a key role in cardiovascular homeostasis

LKB1 Polyclonal Antibody, 100ul[BT-AP05039] Molecular Sciences |PTM:Constitutively sumoylated by SUMO1| SUMO2STK11 (serine threonine kinase 11), which encodes a member of the serine threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of STK11 have been

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