Human Natural Resistance-associated Macrophage Protein 1, NRAMP-1 ELISA Kit , 96T Nucleic Acid Amplification [Isoform 4]: Attenuates the ability

[Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed: 16126907

The encoded protein may play a role in multiple processes including hypotension

This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context

Belongs to the CREG family

This gene was initially mapped to chromosome 14

Human Natural Resistance-associated Macrophage Protein 1, NRAMP-1 ELISA Kit , 96T Nucleic Acid Amplification [Isoform 4]: Attenuates the abilityDivalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own