Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 50ul Apoptosis & Autophagy RING1 and RNF2/RING2

RING1 and RNF2/RING2

thymus and fetal liver

The encoded protein may be involved in sensory neuron regulation and in the modulation of pain

This gene encodes a member of the forkhead class of DNA-binding proteins

and possesses ubiquitin ligase E3 activity

Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 50ul Apoptosis & Autophagy RING1 and RNF2/RING2The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) bladder cancer and osteogenic sarcoma.