PTP IA-2Beta Polyclonal Antibody, 50ul Dry Bath Decreased activity of the encoded

Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria

It is active on peptide linkages involving the carboxyl group of lysine or arginine

The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor

TOP2B encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in TOP2B have been associated with the development of drug resistance

DUF1220 copy number variations in human chromosomal region 1q21

PTP IA-2Beta Polyclonal Antibody, 50ul Dry Bath Decreased activity of the encodedPTPRN2 (protein tyrosine phosphatase, receptor type N2) encodes a protein with sequence similarity to receptor like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3 phosphate and phosphatidylinositol