GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes Receptor-type tyrosine-protein phosphatase eta encoded

Receptor-type tyrosine-protein phosphatase eta encoded by PTPRJ is a member of the protein tyrosine phosphatase (PTP) family

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and mutations in this gene have been associated with different neuromuscular diseases

The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins

Alternatively spliced transcript variants containing different 5' UTRs

GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes Receptor-type tyrosine-protein phosphatase eta encodedThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.