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GFAP Monoclonal Antibody(5C8), 50ul Cell Senescence MARCH1 downregulates the surface expression

SKU: 38419048189

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GFAP Monoclonal Antibody(5C8), 50ul Cell Senescence MARCH1 downregulates the surface expressionThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Description

MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment

This gene is located 7 kb telomeric to gene family member ABCB2

Another cullin

a small neuropeptide

This gene encodes a protein which acts as a receptor for adiponectin

GFAP Monoclonal Antibody(5C8), 50ul Cell Senescence MARCH1 downregulates the surface expressionThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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