Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Catalase is a heme enzyme

Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells

The protein may also be involved in the pathophysiology of depression

This gene contains at least 14 exons| and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons

A second copy of this gene within the centromeric copy of the duplication has been described in the literature

Mutations in this gene are associated with generalized glucocorticoid resistance

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Catalase is a heme enzymeThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.