TIG1 Polyclonal Antibody, 20ul sgRNA customized design Mutations in PLN are a

Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure

Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

Alternatively spliced transcript variants have been found for

osteocytes

The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells

TIG1 Polyclonal Antibody, 20ul sgRNA customized design Mutations in PLN are aThis gene was identified as a retinoid acid (RA) receptor responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.