MIA3 Polyclonal Antibody, 20ul Low-speed Centrifuges Defects in PARK7 are the

Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson disease 7

This gene may also be associated with schizophrenia

Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52

resulting from alternative splicing of the precursor mRNA

Some of the isoforms contain regions of similarity to beta-defensins| a family of antimicrobial peptides

MIA3 Polyclonal Antibody, 20ul Low-speed Centrifuges Defects in PARK7 are theAlthough 2 transmembrane domains are predicted, PubMed: 19269366 showed that it only contains one transmembrane domain. The other predicted transmembrane region is probably a hairpin type region embedded into the membrane, which does not cross the membrane. It is unclear which of the 2 predicted transmembrane regions is the transmembrane or the hairpin type region.,The proline rich region (PRD) mediates the interaction with COPII coat subunits Sec23