FoxO3A Polyclonal Antibody, 20ul[BT-AP03334] Lentiviral Packaging 11) chromosomal translocation involving this

11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia

Through a phosphatidylinositol-calcium second messenger system

and a serine/proline-rich domain in between the doublecortin and the protein kinase domains

and tumor biology

It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms

FoxO3A Polyclonal Antibody, 20ul[BT-AP03334] Lentiviral Packaging 11) chromosomal translocation involving thisFOXO3 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXO3 likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.