Prothrombin Polyclonal Antibody, 100ul[BT-AP07415] Peripheral Blood Separation Tube |PTM:Phosphorylated by CIT (Rho-associated kinase)
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Prothrombin Polyclonal Antibody, 100ul[BT-AP07415] Peripheral Blood Separation Tube |PTM:Phosphorylated by CIT (Rho-associated kinase)Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia.
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