FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture The protein complex formed by

The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs)| and functions as a mediator of the anti-apoptotic signals from TNF receptors

An important paralog of this gene is SLC38A1

a tumor suppressor protein related to APC/beta-catenin signaling pathway

This protein is also overexpressed in type 2 diabetes mellitus

Some modulators interact directly with the basal complex

FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody, 20ul 3D Culture The protein complex formed bydisease: A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X; 11)(q13; q23) with MLL HRX. The result is a rogue activator protein. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin response elements (IREs) and can activate transcription of IGFBP1. Down regulates expression of HIF1A and suppresses hypoxia induced transcriptional activation of HIF1A modulated genes.