Ksr2 Polyclonal Antibody, 100ul Cell Proliferation The encoded protein regulates erythroid

The encoded protein regulates erythroid gene expression| plays a role in the transcriptional switch of globin gene promoters| and it activates many other cellular and viral gene promoters

Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons

Expression of the protein has been observed in various human cancer cell lines established from malignant tumors

and in the paracellular barrier to prevent sodium back-leakage in distal colon

Acts as a GTPase activitor in vitro for CDC42 and RAC1

Ksr2 Polyclonal Antibody, 100ul Cell Proliferation The encoded protein regulates erythroidLocation regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8 mediated signaling. Acts as a negative regulator of MAP3K3 mediated activation of ERK, JNK and NF kappa B pathways, inhibiting MAP3K3 mediated interleukin 8 production.