MDM2 Polyclonal Antibody, 50ul[BT-AP05303] DNA Oligo Synthesis Couples activation of these receptors

Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores| PKC activation| MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1| GRB2| GRAP2| and other signaling molecules

A related pseudogene has been identified on chromosome 18

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and GSTT2B

This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts

MDM2 Polyclonal Antibody, 50ul[BT-AP05303] DNA Oligo Synthesis Couples activation of these receptorsMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many