WNK4 Polyclonal Antibody, 50ul Thermal Control DNA ligase 1 functions in

DNA ligase 1 functions in DNA replication

Alternate allele-specific splice variants

Defects in this gene may be associated with severe combined immunodeficiency (SCID)

At least two transcript variants have been identified for CKS1B

and regulates centriole duplication during the cell cycle

WNK4 Polyclonal Antibody, 50ul Thermal Control DNA ligase 1 functions inThis gene encodes a member of the WNK family of serine threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.