Topo IIIBeta-1 Polyclonal Antibody, 50ul Micro Centrifuge Tubes and mutations in SCNN1B have

and mutations in SCNN1B have been associated with pseudohypoaldosteronism type 1 (PHA1)

Belongs to the EBP2 family

Plays an important role in tumor suppression through p53/TP53 regulation

The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation| apoptosis| differentiation| the stress response| and regulation of immune genes

this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription

Topo IIIBeta-1 Polyclonal Antibody, 50ul Micro Centrifuge Tubes and mutations in SCNN1B haveTOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome