BRCA1 Polyclonal Antibody, 50ul[BT-AP00966] Diagnostic Probes & Oligos This gene encodes a transmembrane

This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth

Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35

a transmembrane segment

Multiple alternatively spliced transcript variants encoding the same protein are observed

is associated with mutations in the ABCA12 gene

BRCA1 Polyclonal Antibody, 50ul[BT-AP00966] Diagnostic Probes & Oligos This gene encodes a transmembraneBRCA1encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein (BRCA1, DNA repair associated) combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi subunit protein complex known as the BRCA1 associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C terminal