MEK-6 Monoclonal Antibody, 100ul[BT-MCA0878] Protein Analysis The encoded protein is similar

The encoded protein is similar in sequence to GPR73

the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53

and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression

These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function

and a mitogen

MEK-6 Monoclonal Antibody, 100ul[BT-MCA0878] Protein Analysis The encoded protein is similarThis gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated