Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette PTM:Phosphorylated on tyrosine residues in

PTM:Phosphorylated on tyrosine residues in response to EGF and PDGF

tumor invasion

This gene is widely expressed in many tissues with the greatest abundance in brain and testis

This gene may be a tumor suppressor gene

May play a role in the maturation and maintenance of the blood-brain barrier (By similarity)

Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette PTM:Phosphorylated on tyrosine residues inCell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical