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Cytokeratin 18 Monoclonal Antibody, 100ul Monoclonal Antibodies This longer isoform may help

SKU: 67322774807

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USD135.00 USD159.00

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Cytokeratin 18 Monoclonal Antibody, 100ul Monoclonal Antibodies This longer isoform may helpKRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

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Description

This longer isoform may help regulate energy metabolism in the mitochondria

The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1

Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients

The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts

Transcripts containing exon IIA or IIB are present in cartilage| but exon IIB is preferentially utilized in transcripts from tendon|disease:Defects in COL11A1 are the cause of Marshall syndrome

Cytokeratin 18 Monoclonal Antibody, 100ul Monoclonal Antibodies This longer isoform may helpKRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

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